| Human Alzheimer's Disease Copy Number PCR Array |
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| The Human Alzheimer's Disease qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in Alzheimer’s disease. The cause of Alzheimer’s disease, the most common form of dementia, has not determined, but it is associated with the accumulation of plaques, tangles, or deposits of amyloid beta protein. It has no treatment or cure, but early diagnosis using cognitive tests and brain scans can help in preparing for care. Several de novo genomic rearrangements, including copy number variations (CNV), have been identified at specific gene loci in patients with Alzheimer’s. The genes on this array encode cytoskeletal components, ion channels, G-protein coupled receptors, proteases, and transcription factors. These proteins regulate processes such as amyloid plaque clearance (including via an immune response), axon growth, axon guidance, central nervous system development (including dysfunction and maintenance), intracellular transport, oxidative stress responses, synaptic plasticity and synaptic transmission. Genes were chosen from the most frequently amplified or deleted genes relevant to Alzheimer’s disease based on a critical review of the primary literature and public databases. This array may serve as a useful tool to help classify samples by genotype and help verify phenotypic biomarkers. The array facilitates the analysis of each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allows routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available |
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Deletions: ERBB4, NRXN1.
Duplications: APP, CHRNA7, CR1, CYFIP1, NIPA1, NIPA2, OR4K2, TUBGCP5.
Behavior, Cognition, Learning & Memory: APP, ATXN1, CHRNA7, NRXN1.
Membrane Potential / Nerve Impulse: APP, ATXN1, CHRNA7, ERBB4, KLK6, NRXN1.
Amyloid Plaque Formation & Clearance: APP, CR1, CSMD1, FPR2, HLA-DPB1, KLK6.
Neurogenesis: APP, CYFIP1, NRXN1, RELN.
Central Nervous System Development: ERBB4, KLK6, NIPA1, NIPA2, RELN.
Axon Growth & Guidance: CYFIP1, RELN.
Neurotransmitter Receptor: CHRNA7.
Ion Transport: CHRNA7, NIPA1, NIPA2, SLC30A3, SLC35F2.
Immune Response: CR1, CSMD1, FPR2, HLA-DPB1.
Oxidative Stress Response: GSTT1.
Transcriptional Regulation: APP, ATXN1, ERBB4, MEOX2
G-Protein Coupled Receptors: FPR2, OR4K2.
Proteases: IMMP2L, KLK6, RELN.
Intracellular Transport: DOPEY2, IMMP2L.
Cell Adhesion & Cytoskeleton: CYFIP1, NRXN1, TUBGCP5
RNA Binding Proteins: ATXN1, HNRNPCL1. |
