肥胖RT2 Profiler? PCR Array可以同時測定84個與肥胖相關的基因。外周激素和中樞神經(jīng)系統(tǒng)的神經(jīng)遞質(zhì)信號間復雜的相互作用網(wǎng)絡在維持能量代謝平衡上起重要作用，從而保持相對穩(wěn)定的體重。本芯片中包含了直接調(diào)節(jié)能量攝入和消耗過程中與肥胖相關的基因。這些基因編碼促進食欲的神經(jīng)肽、激素及受體；厭食神經(jīng)肽、激素及受體；能量消耗相關的中樞和外周信號分子。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測肥胖相關基因的表達。
Orexigenic Genes: Neuropeptides and Receptors: ADRA2B, AGRP, CNR1, GAL, GALR1, MCHR1 (GPR24), HCRT, HCRTR1, NPY, NPY1R, NR3C1 (GRL), OPRK1, OPRM1. Gut Hormone and Receptor: GHRL (Ghrelin / Obestatin), GHSR. Anorectic Genes: Neuropeptides and Receptors: ATRN (Attractin), BDNF, BRS3, CALCA, CALCR, CARTPT (CART), CNTFR, CRHR1, DRD1, DRD2, GH1, GH2, GHR, NMUR1 (GPR66), GRP, GRPR, HRH1, HTR2C, IL1A, IL1B, IL1R1, IL6, IL6R, MC3R, NMB, NMBR, NMU, NTRK2, NTS, NTSR1, PRLHR (GPR10), POMC, SORT1, TRH, UCN, ZFP91. Gut Hormones and Receptors: APOA4, CCK, CCKAR, GLP1R, PYY. Adipocyte-derived Peptides and Receptors: LEP (Leptin), LEPR, TNF. Pancreas Derived Peptides and Receptors: CALCR, CLPS, GCG, GCGR, GLP1R, IAPP, INS, INSR, RAMP3, SST, SSTR2. Genes Related to Energy Expenditure: Adipocyte-Derived Peptides and Receptors: ADIPOQ (ACRP30), ADIPOR1, ADIPOR2, ADRB1, C3, PPARA, PPARG, PPARGC1A, PTPN1, UCP1. CNS-Derived Peptides and Receptors: ADCYAP1, ADCYAP1R1, CPD, CPE, SIGMAR1, THRB. |
