地區(qū): | 上海 |
簡(jiǎn)介: | 上海 |
提供商: | SABio |
服務(wù)名稱: | PCR芯片 |
藥物轉(zhuǎn)運(yùn)蛋白PCR芯片可用于研究表達(dá)轉(zhuǎn)運(yùn)蛋白的84個(gè)關(guān)鍵基因的表達(dá)。轉(zhuǎn)運(yùn)蛋白在藥理學(xué)上發(fā)揮了關(guān)鍵作用,影響藥物進(jìn)出細(xì)胞進(jìn)入和排出。對(duì)吸收、分布、代謝和排泄重要的轉(zhuǎn)運(yùn)蛋白包含于芯片。此外,有助于敏感性和抗腫瘤細(xì)胞的轉(zhuǎn)運(yùn)蛋白也在此芯片上。通過實(shí)時(shí)定量PCR的方法,研究者即能夠利用該芯片簡(jiǎn)單可靠地同時(shí)檢測(cè)與藥物轉(zhuǎn)運(yùn)有關(guān)的基因表達(dá)。 ABC Transporters: ABCA1, ABCA2, ABCA3, ABCA4, ABCA5, ABCA9, ABCA12, ABCA13, ABCB1 (MDR1), ABCB4, ABCB5, ABCB6, ABCB11, ABCC1 (MRP1), ABCC2 (MRP1), ABCC3 (MRP3), ABCC4, ABCC5 (MRP5), ABCC10, ABCC11, ABCC12, ABCD1, ABCD3, ABCD4, ABCF1, ABCG2 (BCRP), ABCG8, TAP1 (ABCB2), TAP2 (ABCB3). SLC Transporters: SLC2A1, SLC2A2, SLC2A3, SLC3A1, SLC3A2, SLC10A1, SLC10A2, SLC15A1, SLC15A2, SLC16A1, SLC16A2, SLC16A3, SLC19A1, SLC19A2, SLC19A3, SLC22A1, SLC22A2, SLC22A3, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC25A13, SLC28A1, SLC28A2, SLC28A3, SLC29A1, SLC29A2, SLC31A1, SLC38A2, SLC38A5, SLC5A1, SLC5A4, SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A9, SLC7A11, SLCO1A2, SLCO1B1, SLCO1B3, SLCO2A1, SLCO2B1, SLCO3A1, SLCO4A1. Other Transporters: Vacuolar H+-ATPase: ATP6V0C. Copper Pumps: ATP7A, ATP7B. Aquaporins: AQP1, AQP7, AQP9. Major Vault Protein: MVP (LRP). Voltage-dependent Anion Channels: VDAC1, VDAC2. |