神經(jīng)形成PCR芯片可用于研究與神經(jīng)形成和神經(jīng)干細(xì)胞分化相關(guān)的84個關(guān)鍵基因的表達(dá)。該芯片包含調(diào)控神經(jīng)形成的基因包括細(xì)胞周期,細(xì)胞增殖,分化,遷移和運(yùn)動相關(guān)的基因。此外,芯片上還有何神經(jīng)干細(xì)胞相關(guān)的生長因子和細(xì)胞因子,神經(jīng)突觸功能,細(xì)胞凋亡,細(xì)胞黏附,神經(jīng)形成的細(xì)胞信號以及轉(zhuǎn)錄調(diào)控相關(guān)的基因。利用實時定量PCR,研究者可以方便并且可信地對與神經(jīng)形成和神經(jīng)干細(xì)胞分化相關(guān)的基因進(jìn)行同時檢測。 Neuronal Migration: ASCL1, CDK5R1, DCX, DRD2, NDN, NEUROG2, NRCAM, NTN1, PAFAH1B1, ROBO1, SLIT2. Cell Differentiation: Neuronal Differentiation: ASCL1, BDNF, BMP2, BMP4, CDK5R1, CDK5RAP2, HES1, HEYL, MEF2C, NEUROD1, NEUROG1, NEUROG2, NOG, NRCAM, OLIG2, PAFAH1B1, PAX3, POU4F1, RTN4, SOX2. Neuronal Cell Fate Determination: ASCL1, NTF3, OLIG2, SOX2. Other Regulators of Cell Differentiation: HDAC4, MDK, NRG1 (HGL), ODZ1, PAX5, PAX6. Synaptic Functions: Regulation of Synaptic Plasticity: ADORA1, APOE, BDNF, DRD2, GRIN1, NF1, S100B. Synaptic Transmission: APOE, CHRM2, CREB1, DLG4 (PSD95), DRD2, FGF2 (BFGF), GRIN1, PAFAH1B1, SOD1, TH. Synaptogenesis: ACHE, NRCAM, POU4F1. Axonogenesis: APBB1, APP, DCX, DRD2, ERBB2 (HER2), MAP2, NOTCH1, NRCAM, PARD3, POU4F1, S100A6, S100B. Growth Factors & Cytokines: Growth Factors: ARTN, BDNF, EGF, FGF2 (BFGF), GDNF, GPI, MDK, NDP, NRG1 (HGL), PTN, S100A6, VEGFA. Cytokines: BMP2, BMP4, BMP8B, CXCL1, GPI, IL3, MDK,PTN, TGFB1. Apoptosis: ADORA1, ADORA2A, ALK, APOE, BCL2, EP300, GDNF, NOTCH2, NTN1, PAX3, RTN4, S100B, VEGFA. Cell Adhesion: DLL1, EFNB1, NRCAM, NRP1, NRP2, RAC1, ROBO1, SLIT2, TNR. Cell Cycle: APBB1, EP300, HDAC4, MDK, MLL, NDN, PARD3, PTN. Signal Transduction: Notch Signaling: APP, ASCL1, DLL1, HES1, HEY1, HEY2, HEYL, NOTCH1, NOTCH2, NRG1 (HGL). WNT Signaling: DVL3, NDP, SHH. TGF? Signaling: BMP2, BMP4, BMP8B, TGFB1. G-Protein Coupled Receptor Signaling: ADORA1, ADORA2A, CHRM2, CXCL1, DRD2. Transcription Factors & Cofactors: APBB1, ASCL1, CREB1, EP300, FLNA, HES1, HEY1, HEY2, HEYL, MEF2C, MLL, NDN, NEUROD1, NEUROG1, NEUROG2, NR2E3, PAX3, PAX5, PAX6, POU3F3, POU4F1, SOX2, SOX8, STAT3. |