上皮細(xì)胞-間質(zhì)轉(zhuǎn)化PCR芯片 Epithelial to Mesenchymal Transition (EMT) PCR Array
科技服務(wù) > PCR芯片實(shí)驗(yàn)服務(wù) > 上皮細(xì)胞-間質(zhì)轉(zhuǎn)化PCR芯片 Epithelial to Mesenchymal Transition (EMT) PCR Array
上皮細(xì)胞-間質(zhì)轉(zhuǎn)化PCR芯片 Epithelial to Mesenchymal Transition (EMT) PCR Array
上皮細(xì)胞-間質(zhì)轉(zhuǎn)化PCR芯片 Epithelial to Mesenchymal Transition (EMT) PCR Array
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| 地區(qū)： | 上海 |
| 簡(jiǎn)介： | 上海 |
| 提供商： | SABio |
| 服務(wù)名稱： | PCR芯片 |
上皮細(xì)胞-間質(zhì)轉(zhuǎn)化PCR芯片可用于研究在這個(gè)過(guò)程中表達(dá)變化或者調(diào)控基因表達(dá)變化的84個(gè)關(guān)鍵基因的表達(dá)。EMT和相互間質(zhì)上皮過(guò)渡（MET）是參與腫瘤的轉(zhuǎn)移和干細(xì)胞分化和發(fā)育的關(guān)鍵步驟。在EMT期間，上皮細(xì)胞失去他們的頂點(diǎn)性和基底極性，破壞其細(xì)胞間的緊密連接，降解基底膜細(xì)胞外基質(zhì)成分成為可遷移的間質(zhì)細(xì)胞。因此該芯片包括細(xì)胞表面受體，細(xì)胞外基質(zhì)，細(xì)胞骨架基因介導(dǎo)的細(xì)胞黏附、遷移、運(yùn)動(dòng)和形態(tài)，控制細(xì)胞分化、發(fā)育、生長(zhǎng)和增殖的基因，以及導(dǎo)致EMT和所有相關(guān)的進(jìn)程的信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄因子基因。通過(guò)實(shí)時(shí)定量PCR的方法，研究者即能夠利用該芯片簡(jiǎn)單可靠地同時(shí)檢測(cè)參與腫瘤代謝或干細(xì)胞分化和發(fā)育有關(guān)的基因表達(dá)。 Genes Up-Regulated During EMT: AHNAK, BMP1, CALD1, CAMK2N1, CDH2, COL1A2, COL3A1, COL5A2, FN1, FOXC2, GNG11, GSC, IGFBP4, ITGA5, ITGAV, MMP2, MMP3, MMP9, MSN, SERPINE1, SNAI1, SNAI2, SNAI3, SOX10, SPARC, STEAP1, TCF4, TIMP1, TMEFF1, TMEM132A, TWIST1, VCAN, VIM, VPS13A, WNT5A, WNT5B. Genes Down-Regulated During EMT: CAV2, CDH1 (E-cadherin), DSP, FGFBP1, IL1RN, KRT19, MST1R, NUDT13, OCLN, PPPDE2, RGS2, SPP1 (Osteopontin), TFPI2, TSPAN13. Differentiation & Development: AKT1, BMP1, BMP2, BMP7, COL3A1, COL5A2, CTNNB1, DSP, ERBB3, F11R, FOXC2, FZD7, GSC, JAG1, KRT14, MST1R, NODAL, NOTCH1, PTP4A1, SMAD2, SNAI1, SNAI2, SOX10, TGFB2, TGFB3, TMEFF1, TWIST1, VCAN, WNT11, WNT5A, WNT5B. Morphogenesis: CTNNB1, FOXC2, JAG1, RAC1, SMAD2, SNAI1, SOX10, TGFB1, TGFB2, TGFB3, TWIST1, WNT11, WNT5A. Cell Growth & Proliferation: AKT1, BMP1, BMP7, CAV2, CTNNB1, EGFR, ERBB3, FGFBP1, FOXC2, IGFBP4, ILK, JAG1, MST1R, NODAL, PDGFRB, TGFB1, TGFB2, TGFB3, TIMP1, VCAN, ZEB1. Migration & Motility: CALD1, CAV2, EGFR, FN1, ITGB1, JAG1, MSN, MST1R, NODAL, PDGFRB, RAC1, STAT3, TGFB1, VIM. Cytoskeleton: CAV2, KRT7, MAP1B, PLEK2, RAC1, VIM. Extracellular Matrix & Cell Adhesion: BMP1, BMP7, CDH1 (E-cadherin), CDH2 (N-cadherin), COL1A2, COL3A1, COL5A2, CTNNB1, DSC2, EGFR, ERBB3, F11R, FN1, FOXC2, ILK, ITGA5, ITGAV, ITGB1, MMP2, MMP3, MMP9, PTK2, RAC1, SERPINE1 (PAI-1), SPP1 (Osteopontin), TGFB1, TGFB2, TIMP1, VCAN. Signaling Pathways: Estrogen Receptor: CAV2, ESR1 (ERa), KRT19, TGFB3. G-Protein Coupled Receptor: AKT1,FZD7, GNG11, RAC1, RGS2. Integrin-Mediated: COL3A1, ILK, ITGA5, ITGAV, ITGB1, PTK2. Notch: FOXC2, JAG1, NOTCH1. Receptor Tyrosine Kinase: EGFR, ERBB3, PDGFRB, RGS2, SPARC. TGF? / BMP: BMP1, BMP2, BMP7, COL3A1, SMAD2, TGFB1, TGFB2, TGFB3. WNT: CTNNB1, FZD7, GSK3B, WNT11, WNT5A, WNT5B. Transcription Factors: CTNNB1, ESR1 (ERa), FOXC2, GSC, NOTCH1, SIP1, SMAD2, SNAI2, SNAI3, SOX10, STAT3, TCF3, TCF4, TWIST1, ZEB1, ZEB2. |
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