干擾素&受體PCR芯片可用于研究由干擾素配體和受體介導(dǎo)的細胞信號調(diào)控和參與信號通路的84個基因的表達。芯片包含了四組主要基因,包括:干擾素(IFN配體)、干擾素受體、干擾素調(diào)節(jié)基因和干擾素誘導(dǎo)基因。通過實時定量PCR的方法,研究者即能夠利用該芯片簡單可靠地同時檢測IFN信號通路相關(guān)的基因表達。 Interferons: Ligands for Interferon-alpha & Interferon-beta Receptors: IFNA1, IFNA4, IFNB1, IFNK, IFNW1. Ligand for Interferon-gamma Receptors: IFNG. Ligands for Hematopoietin & Interferon-class (D200-domain) Receptors: IFNA14, IFNA16, IFNA2, IFNA21, IFNA5, IFNA6, IFNA7, IFNA8, IFNE, IL15. Other Genes: IFRD1, IFRD2, IL28A, IL29, IL6. Interferon Receptors: Interferon-alpha & Interferon-beta Receptors: IFNAR1, IFNAR2. Interferon-gamma Receptors: IFNGR1, IFNGR2. Hematopoietin & Interferon-class (D200-domain) Receptors: CNTFR, CRLF2 (TSLPR), CSF2RA, CSF3R, EBI3, F3, IL20RB (FNDC6), IL10RA, IL10RB, IL11RA, IL12B, IL13RA1, IL20RA, IL21R, IL22RA2, IL28RA, IL2RB, IL2RG, IL31RA, IL3RA, IL4R (CD124), IL5RA (CD125), IL6R, IL7R, IL9R, LEPR, MPL, TTN. Interferon Regulatory Factors: IRF1, IRF2, IRF2BP1, IRF3, IRF4, IRF5, IRF6, IRF7, IRF8. Interferon-Inducible Genes: Response to Virus: CXCL10 (INP10), ISG15 (G1P2), IFI16, IFI35, IFI44, IFI44L, IFIH1, IFIT1, IFIT2, IFITM1 (9-27), IFITM2, MX1, OAS1. Transcriptional Regulators: IFI16, SP110. Other Genes: ADAR, IFI6 (G1P3), IFI27, IFI30, IFIT3, IRGM, PSME1, PYHIN1. |