地區(qū): | 上海 |
簡介: | 上海 |
提供商: | SABio |
服務(wù)名稱: | PCR芯片 |
藥物代謝I期PCR芯片可用于研究參與I期藥物代謝的84個關(guān)鍵基因的表達。I期藥物代謝酶使的化合物更加親水性并且增加對II期藥物代謝完成必須的功能基團。此芯片代表的基因參與I期藥物代謝反應(yīng)包括氧化、還原、水解、環(huán)合、脫環(huán)。在I期藥物代謝反應(yīng)方面發(fā)揮重要作用的細胞色素P450酶家族成員也包含在芯片上。通過實時定量PCR的方法,研究者即能夠利用該芯片簡單可靠地同時檢測與I期藥物代謝有關(guān)的基因表達。 Cytochrome P450: CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP21A2, CYP24A1, CYP26A1, CYP26B1, CYP26C1, CYP27A1, CYP27B1, CYP2A13, CYP2R1, CYP2S1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2W1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, CYP4A22, CYP4B1, CYP4F11, CYP4F12, CYP4F2, CYP4F3, CYP4F8, CYP7A1, CYP7B1, CYP8B1. Alcohol Dehydrogenase: ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, DHRS2, HSD17B10 (HADH2). Esterase: AADAC, CEL, ESD, GZMA, GZMB, UCHL1, UCHL3. Aldehyde Dehydrogenase: ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH8A1, ALDH9A1. Flavin containing Monooxygenase: FMO1, FMO2, FMO3, FMO4, FMO5. Monoamine Oxidase: MAOA, MAOB. Prostaglandin-endoperoxide Synthase: PTGS1, PTGS2. Xanthine Dehydrogenase: XDH. Dihydropyrimidine Dehydrogenase: DPYD |