抗真菌反應(yīng)PCR芯片 Antifungal Response PCR Array
抗真菌反應(yīng)PCR芯片 Antifungal Response PCR Array
抗真菌反應(yīng)PCR芯片 Antifungal Response PCR Array
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| 地區(qū)： | 上海 |
| 提供商： | SABio |
| 服務(wù)名稱： | PCR芯片片 |
抗細(xì)菌反應(yīng)PCR芯片可用于研究參與真菌先天免疫反應(yīng)的84個(gè)關(guān)鍵基因的表達(dá)。三個(gè)不同家族的模式識(shí)別受體（TLRs，NLRS，RIG-I樣受體）啟動(dòng)先天免疫，從而識(shí)別常見病原體如真菌等。在真菌感染的初始階段，TLR、NLR和其他PRRs可以識(shí)別真菌病原體的特征分子，如?-（1,3）-葡聚糖、甘露聚糖、幾丁質(zhì)。PAMP受體結(jié)合并激活先天免疫反應(yīng)，啟動(dòng)下游信號(hào)，并誘導(dǎo)炎性細(xì)胞因子的表達(dá)。對(duì)真菌相關(guān)的PRRs下游信號(hào)通路的了解還不全面，但最近的芯片研究發(fā)現(xiàn)了許多真菌感染初始階段的基因。這一芯片包含了參與真菌病原體識(shí)別的PRRS，代表其下游的信號(hào)轉(zhuǎn)導(dǎo)通路的基因，以及對(duì)白色念珠菌、曲霉菌或隱球菌感染反應(yīng)有關(guān)的基因。通過實(shí)時(shí)定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時(shí)檢測抗真菌反應(yīng)相關(guān)基因的表達(dá)，研究對(duì)真菌病原體的先天免疫的機(jī)制。 Fungal Pattern Recognition Receptors (PRRs): Beta-Glycan Responsive: CD36, CD5, CLEC7A (Dectin-1), ITGAM, ITGB2, SCARF1, TLR2. Mannose/Chitin Responsive: CD207, CD209, CHIA, CLEC6A (Dectin-2), MRC1, TLR2, TLR4. Other: COLEC12, NLRP3, NPTX1, PTX3, TLR9. Signal Transduction: Dectin-1 Signaling Pathway: BCL10, CARD9, CLEC7A (Dectin-1), MALT1, PLCG2, RAF1, SYK. NF?B Signaling Pathway: BCL10, CARD9, CASP1 (ICE), CASP8 (FLICE), CD40 (TNFRSF5), IKBKB, IL10, IL1B, IRAK1, IRAK4, MALT1, MAP3K7 (TAK1), NFKB1, NFKBIA (IkBa/MAD3), STAT1, TNF. Toll-like receptor (TLR) Signaling Pathway: CASP8 (FLICE), CD14, FOS, IRAK1, IRAK4, ITGB2, JUN, MAP2K4 (JNKK1), MAP3K7 (TAK1), MAPK14 (p38 MAPK), MAPK8 (JNK1), MYD88, NFKB1, TIRAP, TLR2, TLR4, TLR9, TRAF6. Complement Signaling Pathway: C3, C5AR1 (GPR77), ITGAM, ITGB2, LYN, MBL2, SYK. Nod-like Receptor (NLR) Signaling Pathway: CARD9, CASP1 (ICE), NLRP3, PYCARD (TMS1/ASC). Inflammation: C3, CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD40 (TNFRSF5), CLEC7A (Dectin-1), CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL2, CXCL9 (MIG), F3, FOS, IL10, IL1A, IL1B, IL2, IL23A, IL6, IL8, ITGB2, LYN, MBL2, MYD88, NFKB1, PTGS2 (COX-2), TIRAP, TLR2, TLR4, TLR9, TNF. Phagocytosis: C3, CD14, CD36, CLEC7A (Dectin-1), COLEC12, FCGR1A, FCN1, MBL2, SFTPD. Genes Responsive to Specific Pathogenic Fungi: Candida albicans: CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD209, CD83, CLEC6A (Dectin-2), CLEC7A (Dectin-1), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL2, CXCL9 (MIG), FCGR1A, FCGR3A, IFNG, IL12B, IL18, IL1A, IL1B, IL1R1, IL23A, IL6, IL8, MYD88, NFKB1, PTGS2 (COX-2), SOCS3, TLR2, TNF. Aspergillus fumigatus: C3, CASP1 (ICE), CASP8 (FLICE), CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD40 (TNFRSF5), CD83, CLEC6A (Dectin-2), CLEC7A (Dectin-1), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL2, CXCL9 (MIG), F2RL1, F3, FCGR1A, FCGR2A, FCN1, IFNG, IL10, IL12A, IL12B, IL18, IL1A, IL1B, IL1R1, IL6, IL8, JUN, MALT1, MAPK14 (p38 MAPK), MBL2, MYD88, NFKBIA (IkBa/MAD3), PTGS2 (COX-2), PTPN6, PTX3, SFTPD, SOCS3, ST3GAL5, STAT1, SYK, TLR2, TLR4, TLR9, TNF. Cryptococcus neoformans: C3, CD5, CCL2 (MCP-1), CD40 (TNFRSF5), SOCS3. |
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