同源異形盒（HOX）基因ChIP PCR芯片 Homeobox (HOX) Genes EpiTect ChIP qPCR Array

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同源異形盒（HOX）基因ChIP PCR芯片 Homeobox (HOX) Genes EpiTect ChIP qPCR Array

同源異形盒（HOX）基因ChIP PCR芯片 Homeobox (HOX) Genes EpiTect ChIP qPCR Array
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簡(jiǎn)介：Homeobox (HOX) Genes EpiTect ChIP qPCR Array 同源異形盒（HOX）基因ChIP PCR芯片
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Homeobox (HOX) Genes EpiTect ChIP qPCR Array

同源異形盒（HOX）基因ChIP PCR芯片
 
ProductSpeciesTechnologyCat. No.
Homeobox (HOX) Genes EpiTect ChIP qPCR ArrayHumanHistone ModificationsGH-083A
Homeobox (HOX) Genes EpiTect ChIP qPCR ArrayMouseHistone ModificationsGM-083A
The Human Homeobox (HOX) Genes EpiTect Chip qPCR Array profiles the histone modification status or “histone code” of 84 HOX genes involved in multicellular organismal development. Histone modifications regulate chromatin structure, regulate gene activity, and contribute to cellular identity. HOX genes encode a group of homeodomain-containing transcription factors, initially described as genes controlling segmental patterning during development, when dramatic changes in the histone code occur. Recently, the importance of homeobox genes and the epigenetic regulation of their expression has been reemphasized by stem cell and cancer researchers. For example, CDX2 transcriptional repression commonly occurs in colon cancer, due to epigenetic histone alterations in its promoter (high H3K4me3 and H3ac with low H3K4me2 and H3K9me3). Although these HOX genes have been grouped according to their established roles in multicellular organismal development, their true function in your cellular systems is waiting to be discovered by you. Using chromatin immunoprecipitation and this real-time PCR Array, you can easily and reliably analyze the histone modification patterns associated with a focused panel of HOX genes.
The EpiTect Chip qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
 
同源異形盒（HOX）基因ChIP PCR芯片分析多細(xì)胞有機(jī)體發(fā)育84個(gè)關(guān)鍵HOX基因的組蛋白修飾狀態(tài)或組蛋白密碼。組蛋白修飾調(diào)節(jié)染色質(zhì)結(jié)構(gòu)，調(diào)節(jié)基因的活性，助于細(xì)胞身份識(shí)別。HOX基因編碼一組包含同源結(jié)構(gòu)域的轉(zhuǎn)錄因子,最初被描述為發(fā)育過(guò)程控制節(jié)段性模式。最近,同源框基因的重要性和表觀遺傳調(diào)控, 被干細(xì)胞和癌癥研究人員再次強(qiáng)調(diào)。例如,CDX2轉(zhuǎn)錄抑制一般發(fā)生在結(jié)腸癌,由其啟動(dòng)上表觀遺傳學(xué)組蛋白修飾引起(高H3K4me3和低H3K4me2 H3ac H3K9me3)。雖然這些HOX基因已經(jīng)被根據(jù)它們?cè)诙嗉?xì)胞生物發(fā)育中扮演的角色進(jìn)行分類(lèi)，它們?cè)诩?xì)胞系統(tǒng)中的真實(shí)功能仍待被你發(fā)掘。通過(guò)染色質(zhì)免疫沉淀和EpiTect ChIP qPCR芯片，可以很簡(jiǎn)易、可靠地分析組蛋白的化學(xué)修飾模式與HOX基因的關(guān)聯(lián)。
 
EpiTect ChIP qPCR僅用于分子生物學(xué)應(yīng)用。本產(chǎn)品不用于疾病的診斷、預(yù)防和治療。

Anatomical Structure Morphogenesis: HOXA11, HOXA4, HOXC10, HOXC13, HOXD3, LBX1, PITX1, POU5F1 (OCT4), SIX2, SIX4. 
Organ Morphogenesis: CDX1, CDX2, HOXA3, HOXA5, MSX1, PAX3, PDHX, PITX2, PITX3, PROX1, SIX6. 
Body Pattern Formation: ALX3, HHEX, HOXA11, HOXA2, HOXA3, HOXA4, HOXA5, HOXB1, LMX1B, PITX2. 
Ectoderm Development: PROX1, VAX2. 
Endoderm Development: HOXC11. 
Brain & Nervous System Development: 
Brain Development: ALX1, DLX2, DMBX1, HESX1, HOXA2, OTX2, SIX3. 
Nervous System Development: ARX, DLX5, DLX6, LBX1, OTP, PAX3, PHOX2B, PROP1, SHOX2. 
Skeletal Development: ALX4, DLX3, DLX5, DLX6, HOXD13, MSX1, MSX2, PITX1, SHOX2. 
Muscle Development: MKX, SIX1. 
Heart Development: ISL1, SHOX2. 
Other HOX Genes Involved In Multicellular Organismal Development: BARX1, CDX4, CUX1, DLX1, DLX4, DRGX, EMX1, EN2, HOXA1, HOXA7, HOXA9, HOXB2, HOXB3, HOXB7, HOXB8, HOXB9, HOXC12, HOXC8, HOXC9, HOXD1, HOXD11, HOXD12, HOXD4, HOXD9, ISL2, LBX2, LMX1A, MEIS1, MEOX1, NKX3-1, OTX1, TLX1, VAX1, VSX1.
HOX Genes Involved In Cell Differentiation: ARX, HHEX, HOPX, LBX1, LMX1B, MIXL1, OTP


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