抗病毒反應(yīng)PCR芯片 Antiviral Response PCR Array

科技服務(wù) > PCR芯片實(shí)驗(yàn)服務(wù) > 抗病毒反應(yīng)PCR芯片 Antiviral Response PCR Array

抗病毒反應(yīng)PCR芯片 Antiviral Response PCR Array

抗病毒反應(yīng)PCR芯片 Antiviral Response PCR Array
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地區(qū):上海
提供商:SABio
服務(wù)名稱:PCR芯片
抗病毒反應(yīng)PCR芯片可用于研究參與病毒先天免疫反應(yīng)的84個(gè)關(guān)鍵基因的表達(dá)。三個(gè)不同家族的模式識(shí)別受體(TLRs,NLRS,RIG-I樣受體)啟動(dòng)先天免疫,從而識(shí)別常見病原體如病毒等。這些受體識(shí)別和結(jié)合病毒DNA和RNA,激活下游的信號(hào)通路,從而誘導(dǎo)炎性細(xì)胞因子的表達(dá),如α和β干擾素。這一芯片包含了TLRs信號(hào)效應(yīng)體基因、NLRS基因和RIG-I樣受體基因,下游信號(hào)通路相關(guān)基因,I型干擾素信號(hào)通路相關(guān)基因,以及干擾素刺激基因(ISGs)。通過實(shí)時(shí)定量PCR的方法,研究者即能夠利用該芯片簡(jiǎn)單可靠地同時(shí)檢測(cè)抗病毒反應(yīng)相關(guān)基因的表達(dá),研究特定病毒感染環(huán)境下,先天免疫信號(hào)網(wǎng)絡(luò)的相互作用。
Toll-Like Receptor Signaling: Receptors and Chaperones: CTSB, CTSL1, CTSS, TLR3, TLR7, TLR8, TLR9. Downstream Signaling: CHUK (IKKa), FOS, IKBKB, IRAK1, IRF3, IRF5, IRF7, JUN, MAP2K1 (MEK1), MAP2K3 (MEK3), MAP3K7 (TAK1), MAPK1 (ERK2), MAPK14 (p38 MAPK), MAPK3 (ERK1), MAPK8 (JNK1), MYD88, NFKB1, NFKBIA (I?Ba/MAD3), RELA, RIPK1, SPP1, TBK1, TICAM1 (TRIF), TNF, TRAF3, TRAF6. Responsive Genes: CCL3 (MIP-1A), CCL5 (RANTES), CD40 (TNFRSF5), CD80, CD86, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL9 (MIG), IFNA1, IFNA2, IFNB1, IL12A, IL12B, IL15, IL1B, IL6. Nod-Like Receptor Signaling: Receptors and Signaling: AIM2, CARD9, CASP1 (ICE), HSP90AA1, MEFV, NLRP3, NOD2, OAS2, PSTPIP1, PYCARD (TMS1/ASC), PYDC1 (POP1), SUGT1. Responsive Genes: IL1B, IL18. RIG-I-Like Receptor Signaling: Receptors and Chaperones: CYLD, DAK, DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), ISG15 (G1P2), TRIM25. Downstream Signaling: ATG5, AZI2, CASP10 (MCH4), CASP8 (FLICE), CHUK (IKKa), DDX3X, FADD, IKBKB, IRF3, IRF7, MAP3K1 (MEKK1), MAP3K7 (TAK1), MAPK14 (p38 MAPK), MAPK8 (JNK1), MAVS, NFKB1, NFKBIA, PIN1, RELA, RIPK1, TBK1, TNF, TRADD, TRAF3, TRAF6. Responsive Genes: CXCL10 (INP10), IFNA1, IFNA2, IFNB1, IL12A, IL12B, IL8. Type-I-Interferon Signaling and Response: Signaling Pathway: IFNA1, IFNA2, IFNAR1, IFNB1, STAT1. Interferon-Stimulated Genes (ISGs): APOBEC3G, IL15, ISG15 (G1P2), MX1, TLR3.


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