血管生成PCR芯片可用于研究與血管生成的生物學過程相關(guān)的84個基因。該芯片包括生長因子及其受體、趨化因子、細胞因子、細胞基質(zhì)、粘附分子、蛋白酶及其抑制劑，以及轉(zhuǎn)錄因子等參與新血管的生成的關(guān)鍵基因。血管生成是多種疾病的病理征兆，如癌癥、貧血、動脈粥樣硬化，及炎性疾病。血管生成還在正常發(fā)育及成人的生理過程中發(fā)揮重要作用，如傷口的愈合和組織再生。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測血管生成相關(guān)基因的表達。
Angiogenic Factors: Growth Factors and Receptors: ANG, ANGPT1, ANGPT2, ANPEP, TYMP, FGF1, FGF2 (bFGF), FIGF (VEGFD), FLT1, JAG1, KDR, NRP1, NRP2, PGF, VEGFA, VEGFB, VEGFC. Adhesion Molecules: BAI1, COL4A3, IL8, NRP1, NRP2. Proteases, inhibitors and Other Matrix Proteins: ANGPTL4, F3, PECAM1, PF4, PROK2, SERPINE1 (PAI-1), SERPINF1. Other Genes: HIF1A, NOS3, SPHK1. Other Factors Involved in Angiogenesis: Cytokines: CCL11 (Eotaxin), CCL2 (MCP-1), CXCL1, CXCL10 (INP10), CXCL5 (ENA78/LIX), CXCL6 (GCP-2), CXCL9 (MIG), EDN1, IFNA1, IFNG, IL1B, IL6, MDK, TNF. Growth Factors and Receptors: CTGF, EFNA1, EFNB2, EGF, EPHB4, FGFR3, HGF, IGF1, ITGB3, PDGFA, S1PR1, TEK (TIE2), TGFA, TGFB1, TGFB2, TGFBR1. Adhesion Molecules: CCL11 (Eotaxin), CCL2 (MCP-1), CDH5, COL18A1, CTGF, ENG (EVI-1), ERBB2 (HER2), FN1, ITGAV, ITGB3, S1PR1, THBS1, THBS2. Proteases, Inhibitors and Other Matrix Proteins: LECT1, LEP, MMP14, MMP2, MMP9, PLAU (uPA), PLG, TIMP1, TIMP2, TIMP3. Other Genes: AKT1, HPSE, ID1, NOTCH4, PTGS1, TIE1. |
