胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array

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胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array

胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
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地區(qū)：上海
簡介：上海
提供商：SABio
服務(wù)名稱：PCR芯片
胰島素信號通路PCR芯片可檢測與胰島素反應(yīng)有關(guān)的84個基因。芯片包含了與胰島素受體有關(guān)的基因和胰島素信號通路的靶基因，碳水化合物、脂類、蛋白代謝有關(guān)的基因和相關(guān)的生物學(xué)反應(yīng)有關(guān)的基因也包括在內(nèi)。此外，芯片還包含PI3K和MAPK信號通路的成員。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測胰島素反應(yīng)相關(guān)的基因表達。
Insulin Receptor-Associated Proteins:
Insulin and Receptors: INS, INSL3, IRS1, IRS2, IRS4, SORBS1.
 Insulin-like Growth Factors and Receptors: IGF1R, IGF2, IGFBP1.
SH3/SH2 Adaptor Protein: CBL, GAB1, GRB2, IRS4, NCK1.
Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1, PTPRF, SHC1. PI-3
Kinase Pathway: Components: AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, MTOR, GSK3A, GSK3B, PDPK1, PIK3CA, PIK3R1, PIK3R2, PRKCG, PRKCI, PRKCZ.
Target Genes: BCL2L1, DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1, SLC2A4, SREBF1, UCP1, VEGFA
MAPK Pathway:
Components: ARAF, BRAF, EIF2B1, GRB2, HRAS, MAP2K1, MAPK1, RAF1, RPS6KA1, RRAS, RRAS2, SHC1, SOS1. Target genes: ANG, BCL2L1, ERCC1, FOS, LDLR, NOS2, UCP1.
Primary Target Genes for Insulin Signaling: CEBPA, CEBPB, FOS, JUN, LEP, PRL.
 Secondary Effector Target Genes for Insulin Signaling: NPY, PCK2, SLC2A1, SLC2A4, TG. Target genes for PPARg: ACOX1, ADRB3, AEBP1, CAP1, CEBPA, CEBPB, PCK2, PPARG, RETN. Target genes for SREBP1: ACACA, FBP1, G6PC, GCK, PCK2, PKM2.
Carbohydrate Metabolism:
 Glucose Metabolism: FBP1, G6PC, GCK, HK2, INS, IRS2, PCK2, PKM2, SLC2A1, SLC2A4, SORBS1.
Glycogen Metabolism: G6PC, GSK3B, PPP1CA.
 Other Genes Related to Carbohydrate Metabolism: ADRB3, GPD1, INSR.
 Lipid Metabolism:
Cholesterol Metabolism:LDLR, SREBF1.
Fatty Acid Metabolism: ACACA, ACOX1, FASN.
 Lipid Transport: LDLR, SORBS1.
 Other Lipid Metabolism Genes: ARAF, BRAF, INS, LEP, PPARG, PRKCG, PRKCI, PRKCZ, RAF1, SHC1.
 Protein Metabolism:
 Protein Amino Acid Dephosphorylation: DUSP14, PPP1CA, PTPN1, PTPRF.
 Protein Amino Acid Phosphorylation: AKT1, AKT2, AKT3, ARAF, BRAF, GSK3A, GSK3B, IGF1R, INSL3, INSR, MAP2K1, MAPK1, PDPK1, PRKCG, PRKCI, PRKCZ, RAF1, RPS6KA1.
 Protein Biosynthesis: ANG, EIF2B1, EIF4EBP1, LDLR, PPP1CA.
 Protein Transport: PRKCI, RRAS2.
 Other Protein Metabolism Genes: AEBP1, CBL, DOK1, DOK2, FRS2, GAB1, IRS1, NOS2, SORBS1, VEGFA.
 Transcription Factors and Regulators:
 DNA-dependent Regulation of Transcription: CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1.
 RNA Polymerase II Transcription Factor Activity: CEBPA, FOS, JUN, SREBF1.
 Transcription Factors: AEBP1, CBL, CEBPA, CEBPB, JUN, PPARG, SREBF1.
 Cell Growth and Differentiation:
 Cell Cycle: MTOR, HK2, HRAS, IGF1R, IGF2, KRAS, MAPK1, VEGFA.
Cell Proliferation: GAB1, IGF1R, IGF2, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGFA.
 Growth Factors and Receptors: GAB1, GRB2, IGF1R, IGF2, IGFBP1, INSR, SHC1, VEGFA.
 Cell differentiation: NOS2, PPARG


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