類黃斑變性PCR芯片可用于研究與老年性黃斑變性(AMD)相關(guān)的84個(gè)基因的表達(dá)。ADM是一類眼科疾病,其分子機(jī)制有待進(jìn)一步研究。該芯片上包含有炎癥以及表皮細(xì)胞血管生成相關(guān)的標(biāo)志物以及AMD脈絡(luò)膜小疣標(biāo)志物,玻璃膜以及視網(wǎng)膜畸形的關(guān)鍵基因。利用實(shí)時(shí)定量PCR,研究者可以方便并且可信地對(duì)與老年性黃斑變性相關(guān)的基因進(jìn)行同時(shí)檢測(cè)。 Anti-angiogenesis: SERPINE1 (PAI-1), SERPINF1, SERPING1. Brusch's membrane markers: FN1, MMP2, MMP9, TIMP1, TIMP3. Choroidal Neovascularization: IGF1, TGFB1, VEGFA. Drusen Markers: APOE, C2, C3, C5, C9, CFB (BF), CFH, CFHR3, CFI, HMOX1, LIPC, TF, VTN. Endothelial Function: ANXA5, CLU, COL14A1, CTGF, EFEMP1, ELN, FBLN5, ICAM1, NOS3 (eNOS), VCAM1, VIM, VWF. Inflammatory Markers: CCL2 (MCP-1), IL6, IL8, PLG, TLR3, TLR4. Oxidative Stress: DICER1, GSTM1 (MGST1), GSTP1, HIF1A, HMOX2, NOS1 (nNOS), SOD2. Retinal Pigment Epithelium Markers: CCL11 (Eotaxin), CRP, CRYAA, CRYAB, CRYGD, CX3CR1, CXCL12 (SDF1), FASLG (TNFSF6), RHO, RLBP1, RPE65, SAG. Other AMD-related Genes: ABCA1, ABCA4, ACE, ALB, ARMS2, CETP, CP, CST3, CTSD, ERCC6, FANCG, GFAP, HMCN1, HTRA1, LEP, LPL, PON1, SCARB1, SLC4A1, SPARC, STMN1, THY1, VLDLR. |